In the nasal cavity, the inferior turbinate and anterior portion of nasal septum is considered as a target site in allergic and nonallergic rhinopathy. These pathophysiology is not known very well but substance P induced neurogenic inflammation
is
very
important role in such a mechanism. Neurogenic inflammation was evoked by capsaicin, a substance that stimulates sensory nerves to release neuropeptide such as substance p(SP) and calcitonin gene related peptide(CGRP) epetide(CRGP). In previous
study,
the substance P immunoreactive nerve fiber were located regionally different in the airway, so neurogenic inflammation was occur in accordance with that nerve fiber. The aim of this study is to investigate whether or not the distribution of
substance P
nerve fiber varied in different localities of nasal mucosa and accord with the sites of neurogenic inflammation(monastral blue labelled vessel) provocated by capsaicin, one of important mechanism of allergic rhinopathy. We used the nasal mucosa
of
guinea pig and to provoke neurogenic inflammation, used capsaicin. We performed immunohistochemical staining to localize the substance P and neuron specific enolase immunoreactive nerve fiber. The results showed that the distribution of substance
P
immunoreactive nerve fiber was more dense in naso- and maxilloturbinate than any other sites. For the second time, it was dense in anterior portion of nasal septum but absent in ethmoturbinates. These distribution was coincide with neuron
specific
enolase immunoreactive nerve fiber, which indicates nonspecific nerve distribution. Capsaicin induced monastral blue labelled vessels were also distributed more densely in naso- and maxilloturbinates and anterior portion of nasal septum, but not
found
in ethmoturbinates. These results suggested that naso- and maxilloturbinate may play an important role in maintenance of nasal physiology and may be a target site in nasal hyperreactivity.
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